Translational Medicine: Discovery and Evaluation of Biomarkers/Pharmacogenomics for the Diagnosis and Personalized Management of Patients
DISEASE SITE: Solid Tumor, Hematological Malignancy
STAGE: Phase I, Phase II, Phase III, Phase IV
TRIAL DESIGN: Cooperative Group
TRIAL TYPE: Biospecimen
ENROLLMENT STATUS: Actively Enrolling
A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue
DISEASE SITE: Colorectal Cancer, Pancreatic Cancer
STAGE: Phase II, Phase III
TRIAL DESIGN: Industry
TRIAL TYPE: Investigational Product
ENROLLMENT STATUS: Actively Enrolling
ClinicalTrials.gov ID: NCT06989437
Managing Symptoms and Psychological Distress During Oral Anti-Cancer Treatment
DISEASE SITE: Solid Tumor
STAGE: Phase III
TRIAL DESIGN: Investigator Initiated
TRIAL TYPE: Interventional
ENROLLMENT STATUS: Actively Enrolling
ClinicalTrials.gov ID: NCT06279013
Molecular Residual Disease in Solid Tumors: A Prospective Study to Collect Clinical Data and Biospecimens to Support Discovery and Development of Cancer Biomarkers
DISEASE SITE: Esophageal Cancer, Melanoma, Non-Small Cell Lung Cancer (NSCLC), Pancreatic Cancer, Solid Tumor
STAGE: Phase I, Phase II
TRIAL DESIGN: Biospecimen
TRIAL TYPE: Biospecimen
ENROLLMENT STATUS: Actively Enrolling
ClinicalTrials.gov ID: NCT06605404
An open-label, single-arm study of prophylaxis of Datopotamab deruxtecan (Dato-DXd) -related stomatitis in eligible patients with metastatic or inoperable locally recurrent breast cancer or locally advanced or metastatic epidermal growth factor receptor-mutated non-small cell lung cancer.
DISEASE SITE: Breast Cancer, Non-Small Cell Lung Cancer (NSCLC)
STAGE: Phase IV
TRIAL DESIGN: Industry
TRIAL TYPE: Interventional, Investigational Product
ENROLLMENT STATUS: Actively Enrolling
ClinicalTrials.gov ID: NCT07357597
Pembrolizumab With or Without Maintenance Sacituzumab Tirumotecan (Sac-TMT; MK-2870) in Metastatic Squamous Non-small Cell Lung Cancer (NSCLC)
DISEASE SITE: Non-Small Cell Lung Cancer (NSCLC)
STAGE: Phase III
TRIAL DESIGN: Industry
TRIAL TYPE: Interventional, Investigational Product
ENROLLMENT STATUS: Actively Enrolling
Clinicaltrials.gov Number: NCT06422143
A Phase IIIb Study to Characterize the Efficacy and Safety of Adjuvant Ribociclib Plus Endocrine Therapy In a Close-to Clinical Practice Patient Population With HR+ HER2− Early Breast Cancer
DISEASE SITE: Breast Cancer
STAGE: Phase III
TRIAL DESIGN: Industry
TRIAL TYPE: Interventional, Investigational Product
ENROLLMENT STATUS: Actively Enrolling
Clinicaltrials.gov Number: NCT05827081
Phase III, Open-label, Study of First-line Dato-DXd in Combination With Rilvegostomig for Advanced Non-squamous NSCLC With High PD-L1 Expression (TC ≥ 50%) and Without Actionable Genomic Alterations
DISEASE SITE: Non-Small Cell Lung Cancer (NSCLC), Solid Tumor
STAGE: Phase III
TRIAL DESIGN: Industry
TRIAL TYPE: Interventional, Investigational Product
ENROLLMENT STATUS: Actively Enrolling
Clinicaltrials.gov Number: NCT06357533
